On the subway and trains
Major stations along the Midosuji Line and other central subway lines generally have elevator access between platforms and street level, and staff are typically available to help bridge the gap between train and platform where a small step or gap exists. Smaller or older stations, particularly on some of the private railway lines out to day-trip destinations, are more inconsistent — checking a specific station's accessibility in advance is worth the extra few minutes.
Booking an accessible hotel room
International hotel chains around Umeda and the riverside generally offer a small number of accessible rooms with wider doorways and roll-in showers, bookable directly by request. Older or smaller Japanese-style accommodation, including many traditional ryokan, is less likely to have been built with step-free access in mind, so it's worth confirming specifics directly with the property rather than relying on a general listing description.
Getting help in advance
For a smoother day at busier stations or attractions, contacting the specific train operator or venue ahead of a visit to arrange platform assistance or confirm lift locations tends to go a long way — station staff in Osaka are generally responsive to this kind of advance request.